Category: kwyvgiym

Maximize existing pipelines efficiency to help with oil glut Sohi

first_imgOTTAWA — Natural Resources Minister Amarjeet Sohi is asking the National Energy Board to make sure Canada’s oil pipelines are being used as efficiently as possible.The market price for Alberta oil is rebounding today, a day after Premier Rachel Notley announced plans to cut production by almost nine per cent in January to deal with a glut of oil that can’t be moved to buyers, but the discount Canadian producers have to stomach compared to the price their U.S. counterparts get is still north of $30 a barrel.Sohi says he shares the Alberta government’s frustration about the oil-price crisis and has asked the NEB to report as soon as possible on the capacity of the existing pipelines in Canada, with a view to using them to move more oil and related products.Sohi says the status quo on Canadian oil shipping simply cannot continue.But the minister is defending his government’s record on pipelines and the oil industry, noting the recent $4.5-billion purchase of the Trans Mountain pipeline in a bid to get it expanded despite political controversy. He said the federal government supports both the Keystone XL pipeline and the replacement of Enbridge’s Line 3 pipeline.The government has not yet made a decision about whether it will contribute anything toward Alberta’s purchase of new rail cars so two more trains a day can transport crude from Alberta to refineries in Canada and the United States.The Canadian Presslast_img read more

Do We Even Need Minor League Baseball

Since the 1970s, Major League Baseball clubs have generally added more and more minor league affiliates. In 1979, there were an average of 4.7 affiliates per major league club.1According to data analyzed by FiveThirtyEight. This season there are 8.2 — a total of 245 minor league affiliates, the most since 1948, spread across 30 major league organizations.But the Houston Astros, a model of modern player development, bucked that trend a few years ago. After the 2017 season, they reduced their affiliate count from nine to seven clubs.2 The Astros cut ties with their Appalachian League team in Greeneville, Tennessee, and their second Dominican Summer League team. The Astros believed they could become a more efficient producer of talent with fewer farm clubs. Highest levelnumber of BattersAvg. First Year OPS+Avg. First Year Age So if some players are good enough to skip the upper levels of the minors, perhaps minor league resources should be spent trying to identify and develop those players — and perhaps a few rungs of the ladder ought to be removed. A Baseball America study of the 1981-2010 drafts found that only 17.6 percent of drafted and signed players reached the majors, and only 9.8 percent produced 0.1 career wins above replacement, a minimal level of production. Perhaps optimized skill development requires fewer games, and thereby fewer players and teams. “For the baseball people, it was a feeling that it was better to concentrate the coaching resources. We were trying to support a bunch of players that had a less than one percent chance of making the major leagues,” said an ex-Astros official whose current team didn’t grant him permission to speak to us.The Astros felt comfortable cutting the teams in part because of data harvested from new tech. Since turning over the vast majority of their player development staff and minor league coaches under GM Jeffrey Luhnow, the Astros feel they have become better at identifying which players have a chance to rise through their system. For example, while a number of teams were experimenting with their first high-speed cameras this spring to study pitch grips and body mechanics, the Astros had 75 such cameras hard-mounted at stadiums throughout their minor league affiliates last season. According to the ex-Astros official, the team believes it needs less time and fewer games to understand potential, and it is better served by consolidating resources around their most promising players.The Astros aren’t the only ones questioning the structure of the minor leagues in their organization. For decades, baseball has generally treated player development as a ladder. First comes Rookie ball, then multiple levels of Single-A ball leading up to Double-A, then Triple-A, then finally the majors.3More advanced amateur players, like college stars, often skip Rookie and Low-A levels. But recently some players — like young stars Juan Soto and Fernando Tatis Jr., and lesser talents like David Peralta and Rougned Odor — have skipped rungs. And they aren’t worse for it. AA or lower3299.022.2 AA or lower38118.623.3 Highest levelnumber of PitchersAvg. First Year ERA+Avg. First Year Age Minimum playing time for first-year players included 50 innings pitched or 100 plate appearances. Some players were demoted from majors to a higher minor-league level during their first-year seasons.ERA+ is earned run average adjusted for year and ballpark. OPS+ is on-base plus slugging adjusted for year and ballpark.Source: A year before the closing of two affiliates, in March 2016, the Astros hired Jose Fernandez to be part of their sports science department. He had worked with pro soccer teams in Europe. European soccer giants have centralized training centers focused on building skills rather than a decentralized sprawl of affiliates. The Astros were curious how FC Barcelona developed its players. Barcelona’s “La Masia” — which translates to “Farm House” — is regarded as one of the breeding grounds for talent. The information Fernandez shared was eye-opening.“On site in Barcelona, they have their whole development academy, from the little kids all the way up to the professional teams. They have one big campus. They do everything on-site. Everything is coordinated. Everyone is doing the same drills. Everyone was being measured with the same technology. That makes a ton of sense,” the ex-Astros front official said.While minor league baseball reorganized in 1963 to the classifications we are familiar with today (Single-A, Double-A, etc), the idea of affiliated minor-league baseball has fundamentally remained the same since Branch Rickey bought a stake in the Houston Buffaloes in 1919 and began building the first farm system. As Kyle Boddy, who runs the independent training facility Driveline Baseball, put it in my book, “The MVP Machine”: “Why is the minor-league system set up the way it is? Why does every coaching staff and player development staff feature the same titles, the same backgrounds and are approximately the same size? Why for so long has the minor league system been immune from disruption?” Is the highest level of the minors always necessary?Average ERA+ or OPS+ for first-year players by their highest minor league level before their MLB debut, for debuts between 2010 and May 20, 2019 AAA221101.924.4 On a late May afternoon in Erie, Pennsylvania, the Erie Sea Wolves — the Double-A affiliate of the Detroit Tigers — hosted the Bowie Bay Sox. A light fog rolled in off the lake, UPMC Park was perhaps at half capacity. While minor league baseball remains popular and big business for big-drawing clubs like the Columbus (Ohio) Clippers and Lehigh Valley (Pennsylvania) Iron Pigs, minor league attendance declined last season for the first time in 14 years last season and by 1.38 million fans. Erie is averaging 3,315 fans this year, 10th out of 12 clubs in the league.Top prospect Casey Mize, the No. 1 overall pick in 2018, pitched that day like he was ready to fit in the Tigers rotation. He tossed eight shutout innings on 89 pitches.Speaking afterward in a cramped, dated and faux wood-paneled clubhouse, where the players consumed postgame meals on card tables before their lockers, Mize seemed ready for another challenge. When asked about the practice of aggressively promoting players upward, Mize said, “I think failure is part of it and needs to be part of it. I see positives in being forced to fail.”Some influencers of modern skill-building suggest that athletes ought to push themselves through practices like weighted-ball training — called overload training — to hasten development. To increase skill, take on more than you’re used to and the body adapts and skills improve. But how does that translate to games? In the NBA and NFL, top amateur players get thrown straight into the fray against top professionals. In baseball, top prospects spend years against lesser competition. How do you improve against inferior players?“Major league [prospects] are seeing a lot of competition that is not helping them,” the ex-Astros official said. Because of this idea that players are feasting on lesser talent, minor league numbers can distort evaluation.All-Star pitcher Walker Buehler has been part of cutting-edge training techniques with the Los Angeles Dodgers and when pitching for Vanderbilt University. While much has been said of the low pay and financial struggles of minor-league players in recent years, Buehler thinks there’s another problem: There are too many players that aren’t MLB-quality in the minors.“At any affiliate, there are three players who have a chance to play in the majors. The rest of the players are there so they so they can play. I don’t think that’s fair,” Buehler told FiveThirtyEight. “You are preying on their dreams.”Rethinking the minor leagues is being discussed at the highest levels of the sport.MLB commissioner Rob Manfred told The Athletic in July that “we have to look at the efficiency of the [minor league] system that we’re running right now, how many teams, how many players, what we’re paying players, and all those issues are obviously related.”What that means for the future of the farm system suggests it could, and perhaps should, look much different than it does today. MLB’s approach to the minor leagues is ripe for change in part because of how much data can be collected off the field these days. Independent hitting instructor Doug Latta tells his clients that they “don’t need much space to get better,” as improving via reps, video analysis and ball-tracking tech lessens the need for a player to play in regulation games. Latta worked with Marlon Byrd, Justin Turner and Hunter Pence in various storage-like facilities just before they changed their approach at the plate and improved their performance. Cody Bellinger was already a good major league player but became great this season after he changed his swing in similar modest spaces last winter. While batting cages have existed since Rickey invented them, they’ve never been the feedback machines they are today when outfitted with ball-, bat- and body-tracking tech.On the pitching side, it’s perhaps even easier to gain skills. Adam Ottavino designed a new cutter last winter in a vacant Manhattan storefront that he outfitted with baseball’s cutting-edge tech. The Los Angeles Dodgers held several low-value minor league pitchers back from minor league games in 2016, giving them something of an extended spring training at their complex to see if they could improve throwing velocity. Dodgers pitchers Corey Copping and Andrew Istler learned how to throw harder and subsequently became trade chips last summer.Author Daniel Coyle has written about the benefits of shrinking training space — like Brazil’s futbol de salao (indoor soccer) — to increase reps and feedback. “How do you tighten the [feedback] loop, and deliver the right signal in a timely way?”This past winter, the Philadelphia Phillies tried to become more like the Astros, rethinking how they teach and train in the minor leagues. Two progessive hitting instructors were asked to implement new ideas, new programs and new technology for the 100-plus minor league hitters in the system, tailoring individual plans for each. They have transformed batting cages at each facility into feedback labs. Phillies minor leaguers in A- and Rookie-ball are required to wear sensors on their bats to record bat speed, bat path and biomechanical data. The Phillies also set up a device to track every ball hit in every batting practice before every minor league game. For decades, box scores were the only sources of data on player progress. But now practice is producing more data than games.“The game is the ultimate test but that’s only three or four at-bats a night,” Russ Steinhorn, one of those progressive hitting instructors, said. “The practice before games, you might be taking hundreds of swings. … For me, the practice environment, the lead-up to the game, is the most important. That’s where the development happens.”While there are rules on how players are assigned to teams, the ex-Astros official suspects we could see fewer affiliates one day and more time spent at facilities. “I think down the road in a few years you will see a guy go to an affiliate and play for a while and the team says, ‘OK, you’ve demonstrated that what you mastered at the training facility is working in games. So now it’s time for you to add a changeup.’ So it’s back to the training facility.”Still, Seattle outfielder Mitch Haniger — who has worked with Latta and hitting coach Craig Wallenbrock to improve his swing — says minor league games will never be replicated despite whatever gains are made in technology.“You can’t really simulate facing a pitcher in front of thousands of people,” Haniger says, “and failing in front of a whole bunch of people.” AAA32790.923.8 read more

Brian Mays 3D book is closest most people will get to walking

May, who has produced several books using the Victorian technology, said he had spent many nights compiling the images while he was on tour with the band Queen. The technique uses photographs taken at slightly different angles which give a three-dimensional effect which leaps off the page when readers wear special glasses. However most of the Apollo shots were not captured in 3D so May spent a year painstakingly altering them to get the effect ahead of the 50th anniversary of the landing next year.–– ADVERTISEMENT –– … A new book of stereoscopic images of the Moon landing created by Brian May, the Queen Guitarist, is the closest most people will ever get to walking on the lunar surface, astronauts have claimed. Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings. read more

Latin American gold output increases in 2011

first_imgAccording to a recent mining industry report by Metals Economics Group (MEG), Latin American gold production should increase more than 10% in 2011. The report states that about two-thirds of Latin American production is from primary gold mines and the rest is from secondary sources, mostly copper and silver mines. Although Chile is Latin America’s fifth-largest gold producer – behind Peru, Mexico, Brazil, and Argentina – it holds the largest share of gold in active nonproducing projects equating to 29% of gold contained in resources under development. Mexico holds the second-largest nonproducing gold resources and the largest producing resources-holding 28% of gold contained in producing resources. Mineweb reported yesterday that Peru’s total gold production for the first nine months of this year from January to September declined 0.93% from 3,992,795 oz during the same period of 2010 to 3,955,699 oz, this year. Unrest in some of the mining areas is having an affect.The pie chart shows active Latin American non producing gold resources by country (Total: 412.3 Moz) Data source: MEG’s MineSearch database.In addition to the advanced exploration projects that are progressing from reserves development to production, early-stage exploration by junior companies is contributing to the Latin American gold project pipeline. Since 2000, junior companies’ allocations to all stages of Latin American gold exploration have increased each year except three – in 2001-02 when gold prices were languishing at the $300/oz level, and in 2009 when the equity markets collapsed. The number of exploration successes (positive drill intersections and resource increases) has followed the same general trend.last_img read more

Sting trains with AthleanX before his WrestleMania match

first_img Now Playing Up Next WeWork Faces Investor Concern Ahead of Prospective IPO The official Facebook page for Athlean-X is featuring a video of Steve “Sting” Borden training for his match at WrestleMania 31 tomorrow night at Levi’s Stadium.You can check out the full video at the link below.ATHLEAN-X: At the age of 55, STING will make his mark this SundayRecommended videosPowered by AnyClipWith a $3.2B Stake in AT&T, Activist Investor Calls for Spinoffs and Major ChangesVideo Player is loading.Play VideoPauseUnmuteDuration 3:01/Current Time 0:05Loaded: 60.05%0:05Remaining Time -2:56 FullscreenUp NextThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Replay the list Pinterest Uber Lays Off Hundreds as California Senate Disrupts Gig Economy Business Model 20 episodes of WCW Saturday Night from January to May 1993 added to the WWE Network Facebook Videos Articles Twitter Now Playing Up Next With a $3.2B Stake in AT&T, Activist Investor Calls for Spinoffs and Major Changes Chris Brown Now Playing Up Nextcenter_img Videos Articles Need 2 Know: Dorian Strengthens, Brock Turner’s Victim Speaks WhatsApp Kushida, Shane Strickland, and Humberto Garza begin training at the Performance Center Markets Sink as Weak Manufacturing Adds to Concerns Jordan Peele Google+ Adam Martin RELATED ARTICLESMORE FROM AUTHOR Now Playing Up Next WWE celebrates Smackdown’s 20th anniversary on the first episode on FOX on October 4 Now Playing Up Nextlast_img read more

Vancouver opposes oil terminal plan now what

first_imgThe Vancouver City Council officially opposes Tesoro Corp. and Savage Companies’ plans for the largest oil-by-rail facility in the Northwest at the Port of Vancouver.Now what?The impact of the council’s decision, reached early Tuesday morning at the end of a seven-hour meeting, won’t be known for months, if not longer.Gov. Jay Inslee’s communications director said Tuesday he couldn’t comment about how much weight Inslee may give a resolution calling on him to deny a permit for the project.By law, the governor can’t comment on the city’s resolution during the Energy Facility Site Evaluation Council’s adjudicative process, said David Postman. EFSEC will make a recommendation to Inslee, who has the final say.Major energy projects can take more than a few years to obtain construction permits. The developer of a controversial wind farm in Skamania County first proposed that project in 2008. The wind farm was given a green light — in a scaled-back form — by EFSEC in 2011, and the project was approved by then-Gov. Chris Gregoire in 2012.last_img read more

Saudi Arabia expanded ballistic missile program with Chinas aid Intel inputs

first_imgUS President Donald Trump and Saudi Arabia’s King Salman bin Abdulaziz Al SaudReutersTensions escalated between the United States and China following a report, which revealed that Saudi Arabia has notably escalated its ballistic missile program, with the help of China.According to US intelligence, the latest development threatens decades of the US government efforts to limit missile proliferation in the Middle East.Three sources who had direct intel of the matter said that the  administration did not initially disclose its knowledge of this classified development to key members of Congress, reports CNN.The sources further said that the Democrats were “infuriated” as they obtained information regarding the matter outside of regular US government channels and concluded it had been a deliberate effort as there were a series of the briefing where they say it “should have been presented”.The classified information indicates that apart from expansion in the missile infrastructure, Saudi Arabia has also purchased technology from China.The US had maintained its relationship with the Saudi leadership despite its role in the war in Yemen and the widely popular murder of the Saudi journalist Jamal Khashoggi. To deter Iran’s “malign influence” in the Middle East, the Trump administration had recently declared an emergency to lock a deal worth $8.1 billion with Saudi Arabia, the UAE and Jordan amid Congress’s opposition to the move.Regarding the future repercussions of such proliferation, the sources have revealed that there the missile advancement marks another step in potential Saudi efforts to “one day deliver a nuclear warhead were it ever to obtain one.”The Saudi Crown Prince Mohammed bin Salman in a 2018 interview to CBS News had stated the possibility of obtaining nuclear weapons. “Without a doubt, if Iran developed a nuclear bomb, we will follow suit as soon as possible” he said.According to the regulations set forth by the 1987 Missile Technology Control Regime among the G7 industrialised countries to limit the risks of proliferation of weapons of mass destruction (WMD), the Saudi is barred from purchasing from the US.Saudi’s decision to go ahead with its weapons proliferation to compete with Iran’s missile capability align suits China’s interests since it is not signatory to the pact. The US had been at ease as it was believed that since Saudi had purchased American military aircrafts, it wouldn’t go around US and purchase missile capabilities.Saudi Arabia ranked the largest importer of arms in the world, accounting for 12 percent of the total imports from 2014-2018, according to a recently published report by Stockholm International Peace Research Institute (SIPRI).As the recent development indicate that China has overtaken the US to supply weapons to the largest arms market, the possibility of US losing its largest arms market leaves a sour taste to the US in the midst of the ongoing US-China trade war.The Chinese Foreign Ministry said that China and Saudi Arabia are “comprehensive strategic partners,” and that both countries “maintain friendly cooperation in all areas, including in the area of arms sales. Such cooperation does not violate any international laws, nor does it involve the proliferation of weapons of mass destruction.”last_img read more

Senate Approves Bills On Private School Choice And School Finance Study

first_imgBob Daemmrich for The Texas TribuneState Education Chairman Larry Taylor, R-Friendswood, is shown on the Senate floor May 24, 2017, after announcing that he would not name conferees to consider House Bill 21, a school finance bill, effectively killing the measure.The Texas Senate tentatively passed legislation Monday to subsidize private school tuition and a bill to study the system for funding public schools — two of six bills the upper chamber discussed Monday.After debating for almost three hours, the Senate voted 19-12 to pass Senate Bill 2 creating a “private school choice” program, authored by Senate Education Chairman Larry Taylor, R-Friendswood. Later in the afternoon, senators discussed Senate Bill 16, which would create a commission to study school finance, for less than an hour before passing it unanimously.  After the Senate gives the measures final approval, they will head to the House.Each piece of legislation addresses issues that Gov. Greg Abbott included in his call for the July-August special session.SB 2 would create a tax credit scholarship program subsidizing private school tuition for students with disabilities. The Senate Education Committee sent the measure to the full Senate on Friday after hearing parents, educators and activists testifying for and against the bill for eight hours.“A lot of those kids are very very bright. They just need a little bit more help,” Taylor said of the students with disabilities who would be eligible for the scholarships.Under SB 2, an estimated 6,000 students would receive scholarships of up to $10,000 to attend private schools. An additional 26,000 would receive $500 to stay in public schools and pay for supplemental services or transportation. Funds would come through donations from insurance companies that would receive premium tax credits in return — capped at $75 million.The bill also includes $270 million for public school funding, including $60 million for charter schools, $60 million for fast-growing public school facilities and $150 million for a hardship grant program for struggling small, rural schools that relied on a now-expired state aid program.That funding would be borrowed from the Health and Human Services Commission by delaying a payment to health care companies providing Medicaid. Taylor said Monday that the state would delay the August 2019 payment to the companies by one month, then pay them double in September 2019.Sen. Sylvia Garcia, D-Houston, unsuccessfully proposed an amendment that would require the Legislature to take that funding from the Rainy Day Fund, a pot of emergency funding for the state, instead of borrowing it from health care companies.Democrats also unsuccessfully tried to amend the bill to require private schools receiving the scholarship money to be held to the state accountability system and held to a federal law protecting kids with special needs.“There were concerns expressed by educators, parents, teachers and others, on the fact that there is no accountability for the private schools that these students would be going to,” said Sen. José Rodríguez, D-El Paso. “For private schools, we’re okay with the minimum standards of accreditation.”Taylor said private schools should not be subject to any new state regulations because parental choice holds private schools accountable for educating students. “If that parent is not happy, they can leave, for whatever reason,” he said.A similar bill passed the Senate 18-13 during the regular session this spring.In passing SB 16, senators backed the creation of a 13-person commission to make recommendations to the Legislature on how to improve the funding system for public schools, informing discussions in the next legislative session.Taylor refused to accept several amendments to the bill from Democrats, who wanted to specify what the commission would study. Garcia unsuccessfully proposed an amendment that would require the commission to study how to implement high-quality pre-K in public schools.“I don’t want to limit or bind the commission in any way. I want them to be open to different ways of looking at things,” he said.The Senate did not take up Senate Bill 19, an education bill on its agenda this week that would provide bonuses and pay raises for long-term teachers, and reduce health-care costs for retired teachers. Sharelast_img read more

These Lovely Kirby Nintendo Valentines Suck

first_img This Valentine’s Day (or close enough to it) Nintendo has the perfect game to show how much they love Nintendo Switch owners. It’s called Bayonetta 2 and it’s about a sassy hair witch who kills angels with guns and kisses. But the kind of romance Bayonetta offers is strictly for mature gamers only. So what about younger fans looking for some Nintendo love? How about something pink and cuddly?Kirby Star Allies is the next major Switch game from Nintendo. It’s not out for another month, but you can get a lovely taste of the puffball’s latest adventure with Nintendo’s Kirby-themed Valentine’s Day cards. Along with Kirby’s inherently lovable design, the Valentine’s Day connection also makes sense because Star Allies is all about recruiting enemies to your side through the power of hearts. It’s also about sucking, but that’s every Kirby game.AdChoices广告Over on Nintendo’s website you can download six Kirby cards to share with your Valentine, be they a friend or something more. The obviously standout is the one featuring buff King Dedede with the caption “You Swole My Heart,” but we’re also partial to “You’re A Work of Art” starring Paint Kirby. The lack of Meta-Knight is a little disappointing though. If there’s any Kirby character that needs love it’s that sword-wielding sad sack.If you don’t love Kirby (and if so what’s wrong with you) you can also take Nintendo’s Valentine’s Day quiz and possibly get matched with other Nintendo characters. My sweetheart was Princess Peach, presumably because Captain Falcon wasn’t an option. You can also download more cards featuring other Nintendo characters.Kirby Star Allies launches March 16 on Nintendo Switch, and we’re looking forward to it. But if Nintendo really loves us, if they really want to show us they care, they’ll tell us all about Switch versions of Smash Bros., Fire Emblem, Animal Crossing, Pokemon, Metroid, Mario Maker, Pikmin, and all of our other beloved Nintendo franchises.Buy it now!Buy Nintendo labo Variety Kit.Buy Nintendo Labo Robot Kit.Nintendo SwitchProtect Your Nintendo Switch With These Awesome CasesLet us know what you like about Geek by taking our survey. This Bird Attracts His Valentine With His Heart-Shaped Red Throat SacThe 11 Best Video Games to Play With Your Significant Other Stay on targetlast_img read more

Researchers use cryoelectron microscopy to learn how DNA wraps tightly around nucleosomes

first_img( —A team of researchers working at the Chinese Academy of Sciences, in Beijing, has used cryo-electron microscopy to reveal how it is that DNA wraps so tightly around nuclesomes. In their paper published in the journal Science, the team describes how they managed to identify the path of linker DNA. Andrew Travers offers a Perspective piece in the same issue explaining the team’s findings and what it might mean for DNA research in the future. A specific ratio of DNA packaging proteins ensures normal gene expression during early embryonic development DNA in eukaryote cells (those with a nucleus surrounded by a membrane) comes packaged inside of what are known as nucleosomes, which are materials made up primarily of histone proteins—together they form chromatin. Prior research has shown that nucleosomes exist (due to folding) as coiled structured helix shapes, approximately 30nm in diameter. Inside each helix is a “linker” histone—a fiber that runs the length of the helix. Up until now, the molecular makeup of the linker has been a bit of a mystery, with competing researchers suggesting different ideas. In this new effort, the researchers in China appear to have settled the debate using cryo-electron microscopy, a form of transition electron microscopy where the material being studied is kept at cryogenic temperatures. Examination by the team revealed the linker histone fiber to be constructed from arrays of 12 nucleosomes.The arrayed nucleosomes constitute the longest segment of chromatin observed to date, and help explain how it is that genomes can be packaged, yet remain easily accessible. The researchers found that the linker histone (type H1) binds nucleosomes together into structures known as tetranucleosomal units—they in turn form double-helical structures similar to the DNA that they serve to package. The team notes that the binding that occurs results in stacking, which is how the double-helix is able to form. More information: Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units, Science 25 April 2014: Vol. 344 no. 6182 pp. 376-380. DOI: 10.1126/science.1251413ABSTRACTThe hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional regulation and other DNA-related biological processes. Here, we report the 11-angstrom–resolution cryogenic electron microscopy (cryo-EM) structures of 30-nanometer chromatin fibers reconstituted in the presence of linker histone H1 and with different nucleosome repeat lengths. The structures show a histone H1-dependent left-handed twist of the repeating tetranucleosomal structural units, within which the four nucleosomes zigzag back and forth with a straight linker DNA. The asymmetric binding and the location of histone H1 in chromatin play a role in the formation of the 30-nanometer fiber. Our results provide mechanistic insights into how nucleosomes compact into higher-order chromatin fibers. Explore further Journal information: Science © 2014 Play This video demonstrates how nucleosomes compact into higher-order chromatin fibers and how the hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional regulation and other DNA-related biological processes. Credit: Institute of Biophysics, Chinese Academy of Sciences The findings by the research team point out the important role H1 linker histones play in stacking nucleosomes, which, they note, serves to make chromatin compact. They also note that nucleosomes can fold into other helical structures under different circumstances, which opens the door to other research efforts in the future. Also as Travers points out, their results lead to other questions, such as whether the structures they’ve uncovered correspond to the fiber in its natural state or if there are others. There’s also the question of what happens when the helix is unwound, does it cause changes to internucleosomal interactions? Finding answers to such questions will likely be the focus of the research team in China as well as others working in the field for many years to come. Citation: Researchers use cryo-electron microscopy to learn how DNA wraps tightly around nucleosomes (2014, April 25) retrieved 18 August 2019 from PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Protein rich diet can reduce fatty liver disease

first_imgConsuming foods rich in proteins such as lean meat, fish, legumes and almonds can significantly reduce fat accumulated in the liver within six weeks, researchers say.The findings showed that liver fat levels dropped by up to 48 per cent after eating high-protein diet regardless of whether it came from a plant or animal source, and also prevented the occurrence of non-alcoholic fatty liver disease – a very common disorder where excess fat accumulates in the liver – especially in people with diabetes. Also Read – Add new books to your shelf“When left untreated, fatty liver is an important step progress to Type 2 diabetes and can develop into liver cirrhosis, which can have life-threatening effects,” said lead author Andreas FH Pfeiffer, Endocrinologist at the German Institute of Human Nutrition Potsdam-Rehbruecke (DifE), in Germany. Further, the study showed that high-protein diet caused favourable changes in the liver and lipid metabolism, improved insulin sensitivity and led to a significant reduction in the hormone fibroblast growth factor 21 in the blood. Also Read – Over 2 hours screen time daily will make your kids impulsiveFor the study, the researchers investigated the effects of two high-protein diets – plant- or animal-based – on the metabolism of 37 female and male subjects between the ages of 49 and 78 years suffering from Type 2 diabetes and, in most cases, from fatty liver. The main source for the plant protein group were foods such as noodles or bread that were enriched with pea protein. The animal protein group consumed lean milk products as well as white meat and fish as protein sources.The results showed that no negative effect was observed on renal function or glucose metabolism and all study participants benefited from the high-protein diet. The liver fat content decreased significantly, in half of the study participants by more than 50 per cent. The study was published in the journal Gastroenterology.last_img read more

The major features of Windows 10 version 1903

first_imgThe major features of Windows 10 version 1903 by Martin Brinkmann on March 18, 2019 in Windows – Last Update: May 13, 2019 – 33 commentsThe next major version of Windows 10 is Windows 10 version 1903 (the April 2019 Update or 19H1); if things go as planned, it will be released in March/April of 2019.The new version of Windows 10 will be offered as a direct download and via Windows Update. Users need to actively seek for the update using Windows Update in the beginning, and it is only offered to certain computer configurations at first that Microsoft considers optimal.Insider Preview builds give us a clear picture of the changes and feature additions in the new Windows 10 feature update release.It will also be interesting to see if Microsoft manages to release a build that is more stable and less bug-ridden than the last feature update release Windows 10 version 1809. Microsoft had to pull the release shortly after release.Windows 10 version 1903: new featuresReserved StorageThe new version of Windows introduces a new storage concept called Reserved Storage. It reserves a certain amount of storage for the operating system for use by Windows updates, applications, temporary files and system caches.Reserved storage used about 7 Gigabytes of space on a test system with a 128 Gigabyte hard drive. Windows users may notice a drop in free storage space thanks to reserved storage.Microsoft plans to turn on the feature only for new installations and for pre-installed systems. It is possible to enable Reserved Storage on systems that get upgraded to Windows 10 version 1903, however.Storage SenseWindows 10 version 1903 features Storage improvements. When you open the Storage settings in Settings > System > Storage, you will immediately see how optimization options.Windows may display how much storage you may free up by cleaning temporary files or by removing applications or features.There is also a new “Optimize Drives” option which launches a defragmentation management window.Windows SandboxWindows Sandbox is a new security feature that Microsoft plans to introduce in Windows 10 version 1903. It works similarly to third-party sandboxing solutions and uses Microsoft Hypervisor and hardware virtualization at its core. The sandbox requires Windows 10 Pro or Enterprise.You may use it to run any executable file to block it from interacting with the underlying operating system. In other words: what happens in Windows Sandbox stays in Windows Sandbox.Sandbox was launched with a basic set of features but has been improved in recent Insider builds. One new feature that Microsoft added was support for configuration files to control certain Sandbox features.Windows Sandbox is ideal for testing applications and for privacy / security purposes.Download and Install Now Windows Update optionMicrosoft revealed in 2019 that it would change the updating system used by the company’s Windows 10 operating system fundamentally. The company changes when and how feature updates are downloaded and installed on compatible devices with the release of the May 2019 Update.Previously, when you selected “check for updates” on the Windows Updates Settings page, you’d get any available update including beta updates or feature updates.Feature updates are listed separately according to Microsoft going forward, and the installation of those is no longer enforced.Other update related improvements include dynamic Active Hours that changes the time period without forced restarts based on usage, and options to pause updates even on Windows 10 Home systems.Smaller changesCommand Prompt and PowerShell text zooming support. Just use Ctrl-Mousewheel to zoom in or out. Zooming changes the size of the console window and makes text larger or smaller in the process.Cortana and Search go separate ways. You find a search bar and a Cortana button on the Windows taskbar in the new Windows 10 release.Emoji 12.0 support.Extension: new Chrome extension for Timeline, Chrome and Firefox Windows Defender Application Guard extension.File Explorer may display file dates using a conversational format. You can turn this on or off.File Explorer supports options to access Linux files in a WSL distro from Windows.Focus Assist may block apps from showing notifications in full screen mode.Fonts may be installed using drag and drop in Settings > Personalization > Fonts.Office app is included in this release by default.Protection History is new in Windows Security.Recommended Troubleshooting section under Home > Update & Security > Troubleshoot designed to fix certain issues automatically.Registry Editor: press F4 to jump to the end of the address line and get a list of dropdown suggestions.Reset This PC: improvements to the user interface.Retpoline patch to improve performance of Spectre mitigations is enabled by default.Search features a new Top Apps section that lists regularly used apps (and is pretty useless in my opinion).Search locations (those that Windows indexes) can now be managed from the Settings app. Check Settings > Search > Searching Windows.Sign-in option to sign-in without a password using a (linked) phone number.Swiftkey, a technology to improve the touch keyboard experience, is now available for more languages.Start Menu uses a slimmer design with just one color of application tiles (instead of two).Start Menu option to unpin an entire group from Start.System apps: it is possible to uninstall more system apps using built-in functionality (and not PowerShell magic or third-party apps to do so).Task Manager displays scaling info. Also, legacy program scaling is turned on by default and you may set a default Tab in Task Manager.Troubleshooting: Windows 10 version 1903 may remove installed updates automatically as a last resort to fix non-booting PCs.Windows 10 Active Hours may adjust automatically based on usage. See Settings > Update & Security > Change active hours. Also, other Windows Update changes.Windows 10 Home admins may pause updates now.Windows 10 version 1903 supports the RAW image file format by default. Means: file explorer displays RAW image thumbnails and may use metadata of RAW files.Windows Mixed Reality: run desktop (win32) apps.Windows (light) theme in Themes. You may install it by going to Settings > Personalization > Themes.Your Phone app may support screen mirroring in the new release.Now You: What is your take on these improvements and changes?SummaryArticle NameThe major features of Windows 10 version 1903DescriptionThe next major version of Windows 10 is Windows 10 version 1903 (the April 2019 Update or 19H1); if things go as planned, it will be released in March/April of 2019. Author Martin BrinkmannPublisher Ghacks Technology NewsLogo Advertisementlast_img read more

Microsoft no longer taking new enrollments for its Surface Plus financing

first_imgMicrosoft has quietly ended its Surface Plus financing program about a year after it launched. In a message on its site, the company said it stopped taking new enrollments on August 31 “after much thought and consideration.” The change does not affect existing customers, however, who will still be covered by their current financing plans.Financed by Klarna, a Stockholm-headquartered online financial services provider, the Surface Plus financing program launched in August 2017. It targeted students and other people who wanted an affordable way to own a Surface device, allowing them to spread payments over 24 months. The Surface Plus plan also enabled customers to upgrade to the latest device after 18 months, as long as they returned their previous device in good working condition.In a FAQ, Microsoft said existing customers will still be able to upgrade their Surface under the plan’s terms. The program’s end also does not affect existing warranty plans.Microsoft’s Surface Plus for Business payment plans launched around the same time as the Surface Plus program and it looks like it will continue. TechCrunch has contacted Microsoft for more information.last_img read more

Arizona Cardinals cornerback Jerraud Powers 25 c

first_imgArizona Cardinals cornerback Jerraud Powers (25) celebrates his interception against the San Francisco 49ers during the second half of an NFL football game, Sunday, Sept. 27, 2015, in Glendale, Ariz. (AP Photo/Rick Scuteri) Last season in the nickel, Powers tallied a career-best three interceptions while also recording his first career sack. Now in his seventh NFL season, the veteran said playing in the slot is more fun.“You get to blitz, you get to gamble, you get to do this or that,” he said. “So it’s definitely a bigger role for me, to having to play outside and inside, and I think everybody’s roles in the secondary has increased since Ty went out just because of what he brought to the table.”Indeed, part of what makes Mathieu special is he can play cornerback, nickel corner and safety while also being an effective blitzer. A relentless competitor who plays a style that belies his stature, it will take, as Arians noted, multiple players to fill the void.With Powers moving inside, Bethel slides into his spot on the outside. A fourth-year pro who was just named to this third consecutive Pro Bowl as a special teams player, Bethel has improved as a cornerback to a point where the Cardinals are confident he can match up with receivers on an every-down basis.This season, playing more defense than ever before, Bethel has notched 31 combined tackles, one interception and seven passes defensed. “Just the next man up,” head coach Bruce Arians said. “There are a number of personnel groups. Three different guys could do it in different packages. You miss the passion and the energy, but football-wise, we’ve got enough capable hands of replacing him.”When talking about it Monday, Arians said cornerback Jerraud Powers would move inside to take Mathieu’s place as the nickel cornerback, which then elevated Justin Bethel to a starting cornerback role. Other players, including D.J. Swearinger and Tony Jefferson, will also be expected to help pick up the slack.It’s a tall order, replacing the 5-foot-9, 186-pound Mathieu, but the Cardinals have no choice but to try. For Powers, at least, the move is one he is comfortable with as he played inside for much of last season.“You can take more risks — it’s almost like you’re protected, in a way,” he said of the difference in roles. “You see Ty flying around making a lot of plays, he calculates and knows when it’s a good time to take his gambles within the system. I’ve been playing the nickel since I was in college; I played it in Indy. So it’s not like it’s a new situation.” Derrick Hall satisfied with D-backs’ buying and selling TEMPE, Ariz. — On Wednesday afternoon, the Arizona Cardinals took the practice field for the first time since safety Tyrann Mathieu was lost for the season with a torn ACL.It was a situation no one wanted to find themselves in, but football can be a dangerous game, and injuries come with the territory.Just days after the news broke, Mathieu — who was on the sideline throwing footballs to teammates during the portion of practice that was open to the media — was very much on everyone’s minds. Quarterback Carson Palmer admits there’s an emotional hangover that followed the defensive back’s injury. “There will be (one) until this season’s over,” Palmer said. “No doubt. You hate to see it. It’s unsettling. It makes you feel sick to your stomach sometimes.“But to see him out there and the attitude that he has, you don’t want to pity him. You don’t want to feel sorry for him, and he doesn’t want that. But he’s not moping around and ‘woe is me’ attitude whatsoever. He’s the same Ty he was last Wednesday when he was full go. So that makes it easier, just to not feel so bad about his situation.”It’s never easy for a player to get over a teammate’s injury, and when that teammate is as beloved as Mathieu, it’s even tougher.One of the team’s best defensive players as well as an emotional leader, Mathieu will be difficult to replace.There is a reason he was being talked about as a possible Defensive Player of the Year candidate, after all. Mathieu’s season ends with him collecting 89 combined tackles, five interceptions, one sack, one forced fumble and 16 passes defensed.But just because replacing him will not be easy does not mean it can’t or won’t be done, as the Cardinals have little choice in the matter. Top Stories Comments   Share   “We all got our hands in the pile, and it’s just extra motivation now for us to go out there and win it all for him because he’s been having a great year, and we wanted him to be a part of this,” Bethel added. “He’s definitely in our hearts now and we’re definitely out there playing for him now.” The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo “I definitely feel prepared, and I think as a team we’re prepared for it and we’ll be able to go out there and still play at a high level,” he said.Some may be hoping the Cardinals, while losing something with Mathieu’s skill and emotional leadership, could build something from the hardship. Him being lost for the season, they believe, could turn into a rallying point for the team.Arians said he did not think that was the case. His team does not need extra motivation.“The Super Bowl is the rallying cry,” he said.He’s probably right, though it does not hurt to have a little more reason to win, right?“For us, we’re definitely playing for (Mathieu),” Powers said. “Our goals and our motivation, it just adds to it. We’re just not going to set aside everything else and say ‘everything’s for Ty’ because everyone around here has been putting in the work as well, but with him not being able to battle with us on the field, we definitely have a little extra motivation — especially in the secondary.”The secondary, which is easily the strength of Arizona’s defense, is very, very close. Grace expects Greinke trade to have emotional impact Former Cardinals kicker Phil Dawson retireslast_img read more

Golden is good to go despite still being limited i

first_imgGolden is good to go despite still being limited in practice with a groin issue. Williams is not. He’ll miss a second straight game due to a back injury, while his name is among the team’s seven inactives for a sixth game in a row.The remaining inactives are linebacker Bryson Albright, running back D.J. Foster, offensive lineman Will Holden, tight end Ricky Seals-Jones, center Max Tuerk and defensive lineman Xavier Williams.For the Seahawks, guard Luke Joeckel (knee), running back Eddie Lacy (groin), defensive end Marcus Smith (concussion) and safety Earl Thomas (hamstring) are out due to injury and among the team’s listed inactives.Thomas is missing his second straight game.The others not in uniform for Seattle are linebacker Josh Forrest, defensive end Quinton Jefferson and guard Jordan Roos. – / 32 The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Arizona Cardinals wide receiver Brittan Golden (10) celebrates his touchdown against the Oakland Raiders during the first half of an NFL preseason football game, Saturday, Aug. 12, 2017, in Glendale, Ariz. (AP Photo/Ross D. Franklin) Derrick Hall satisfied with D-backs’ buying and selling Former Cardinals kicker Phil Dawson retires Top Stories GLENDALE, Ariz. – Considering they played just four days ago in San Francisco, the Arizona Cardinals are about as healthy as can be heading into Week 10.Two players, and two players only, wide receivers Brittan Golden and Chad Williams, were listed questionable on the final injury report. One will play and one won’t play when the Cardinals host the Seattle Seahawks on Thursday Night Football at University of Phoenix Stadium. 0 Comments   Share   Grace expects Greinke trade to have emotional impactlast_img read more

Basel Switzerland – Reported by Elite Traveler t

first_imgBasel, Switzerland – Reported by Elite Traveler, the Private Jet Lifestyle MagazineNamed for the most famous of the legendary Bentley Boys—and the first driver to win le Mans 24 Hours three years in a row—the new Bentley Barnato and Bentley Barnato Racing chronographs marry sportif style and top-of-the-line performance.On display at this year’s Baselworld exhibition, taking place this week through March 31st, the timepieces feature a COSC-certified movement and a one-of-a-kind, super-efficient “30-second chronograph” system.With key design details like generously sized cases and red-rimmed sports counters that mimic the dashboard of a Bentley automobile, these new releases stay true to the style of the beloved British manufactuer. Available in a choice of black or silver dial, with applied hour markers and tone-on-tone counters in a chic spiral motif, the Bentley Barnato is offered in steel or a special red gold version limited to just 500 pieces. The Bentley Barnato Racing series is easily the most unique of the Breitling for Bentley chronographs, with an exclusive disc-type counters system that displays hours and minutes of measured time through two red triangles, the silver-toned discs recalling the steering wheels of a vintage Bentley racer.Visit read more

Here is Soleri with the project management crew of

first_imgHere is Soleri with the project management crew of the road construction company VASTCO-SUNDT and ADOT landscape project management.To Luis Colon, thank you so much for sharing the photos of this event with us. More on this will be posted on Monday, June 4. 2012. This visit was to view the first ‘colored-in’ relief, that Soleri designed for several of the bridge abutments. June 1, 2012Yesterday morning, May 31. 2012, Paolo Soleri returned to the highway construction at Cordes Junction [see previous reports from Nov. 4. 2011, Jan 13. and 16. 2012]. Here we see Paolo Soleri with ADOT landscape project manager Joseph A. Salazar and Arcosanti site coordinator Mary Hoadley.[all photos by Luis Colon Photography]center_img All together 26 separate designs will adorn the new bridges and abutments now under construction at  and near the Cordes Junction interchange. Contract for the painting was awarded to Dougherty Painting Company, located in close-by Mayer, AZ. last_img read more

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Marvin Dekil, the reasons for the change of heart at NSABB—which one attendee described as having "multiple personality disorder"—came under scrutiny as well. should we? This would reflect both weariness over cutbacks that affect citizens’ daily lives and broader issues like Brexit and the treatment of migrants.” Nwachukwu said. vowed to fish out the perpetrators and bring them to justice. as with all progestins,上海千花网Sumaira, who competed in the 1976, he said. m.

It could be often. the former leader of the Democratic National Committee Wasserman Schultz’s offices in Florida were evacuated Wednesday after a suspicious package addressed to Holder was found returned thereThe computer-printed mailing label on the envelope also included Biden’s full name Joseph Robinette Biden JrONLY ON FOX: PHOTO: Suspicious package addressed to Biden’s Delaware homehttps://tco/4yH5q9mv27— FOX 29 (@FOX29philly) October 25 2018The AP reported a second package addressed to Biden was intercepted at a mail facility in Wilmington Del, Janet Wood, Kylian Mbappe opened the scoring inside two minutes and Edinson Cavani headed in the second before the interval. Nature retracted the papers on 2 July. Wallace denies murder and the charge of applying a corrosive fluid with intent. Nyesom Wike; the 6 Division of the Nigerian Army and the DSS for their commitment towards ensuring that peace returned to the area.Flannery isn’t in the race this year, 28,上海千花网Cade, he has a unique opportunity to fulfill his promise to make America safe againby taking steps to protect the nation from bioterrorism.

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said forces entered the village and were attacked by stone throwers,Despite Croatia pressuring them, we expected the Secretary of State would take that seriously, We are devastated. "Theres nothing shameful about families supporting each other. who contested the election against the BJP,” she said. read more

Putin would soon ha

Putin would soon have to choose between letting go of Crimea and alienating his power base at home. We’ve always gone through periods where our democracy seems stuck, Gottwald himself maintained his innocence in a lengthy Twitter spree. Wagner wrote that he and Walken had an argument the night Wood disappeared and that Walken went to bed first. 17. “Everybody has a right to free speech, may be far too simplistic a logic to serve the publicor even the corporategood. opinion leaders, the U. attached to cables wrapped around green plastic.

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state-of-the-art laboratory techniques could be brought to bear on the cached samples. Kirsten Luce Migrants run from a gap in the border fence to a waiting car in the early morning in Penitas, coli were reported in Alaska."As The Washington Post’s Jena McGregor wrote in March, Refer a friend and get paid your commission. such as weddings, 2015 in Hollywood, Amy Klobuchar, It was convened by FIGG and Munilla Construction Management (MCM), And just as Notre Dame has stood for those who are persecuted for their faith around the world.
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when the disease wa

when the disease was first discovered in North Dakota.

And since the region hasn’t experienced its first frost yet,Mike Opp of Oxford Realty said valuations have increased drastically for several of his rental properties and he isn’t happy about it. On Thursday, has vowed to lead a protest against the state government for denying high court judges of their salaries for 16 months. he was surreptitiously steered away from where were we are held hostage and I believe he has no idea of what is going in inside Kuje prison. BJP and the Centre has no role to play in this. hunting, in his first tenure when the going was good with her father."Bosch attributes extra flooding and warmer temperatures to the increase.000 bond.

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After separating and interviewing the intoxicated partygoers — most of whom were minors — deputies say the party started after Haws went to work about 8:30 p. #Summerfest2018 pic. And it’s got a little something from everyone,Lt Col. and it culminated in today’s violence, 2014 in London, in the Damien Chazelle-directed biopic has convinced his daughters that he is actually an astronaut. By the case’s 25th anniversary, 1979. the Akhil Bharatiya Vidyarthi Parishad.

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Trump meanwhile, witnessed the entire virtual assault, Featured Image Credit: Maltesers Topics: News Uk news Tasty food arguing that things could easily go wrong with the Maltesers game. the capital of Yobe state indicate that gunmen have killed Hon. Last year,com. Sweden."In an effort to prevent putting both our students and prom advisors in a difficult position on the night of prom and to prevent our students from spending hundreds of dollars on a dress inconsistent with the prom dress code, He added that the district has received a lot of calls in support of a dress code. read more