WHO: initial analysis of Pakistani H5N1 suggests no dangerous mutations

first_imgJan 3, 2008 (CIDRAP News) – An official from the World Health Organization (WHO) today shared results of initial genetic sequencing tests on H5N1 avian influenza samples from a man who died of the disease in Pakistan that suggest the strain doesn’t have the capacity for widespread transmission.John Rainford, a WHO spokesman in Geneva, told CIDRAP News that the genetic sequencing involved two clinical samples from a 25-year-old man from the Peshawar area who was recently announced as the first confirmed human H5N1 case-patient and fatality in Pakistan.The man was part of a family cluster of suspected H5N1 cases which sparked global concern that the virus had mutated into a form that could enable widespread human-to-human transmission. However, the WHO said in a previous statement that while the Pakistani cases suggest a rare instance of human-to-human transmission, the virus did not spread beyond the family.Rainford said preliminary sequencing of the hemagglutinin and neuraminidase genes from the specimens was performed at the WHO collaborating center in London. Tests completed so far show the hemagglutinin amino acid sequence is identical to some of the recent clade 2.2 viruses that have been isolated from chickens in other outbreaks in the region, he said.WHO virologists say the findings, along with recent field investigations, suggest that the H5N1 viruses in Pakistan have not gained the capacity for widespread human-to-human transmission, reported Rainford.In addition, neither analysis by WHO collaborating scientists of the neuraminidase gene nor partial sequencing of the M2 gene shows mutations that are known to be associated with antiviral resistance, Rainford said. “This indicates oseltamivir and amantadine should be inhibitory for the virus,” he added.Rainford said full genome sequencing is in progress.The WHO praises Pakistan’s timely investigation and management of suspected H5N1 cases, Rainford said. “[This] has provided reassurance about the lack of community H5N1 transmission, an effort that deserves appreciation and support.”In other avian flu developments, the WHO yesterday confirmed two fatal H5N1 cases in women from Egypt whose deaths were recently reported in the media. One was a 25-year-old from Dakahlyah governorate who got sick Dec 26, was hospitalized the next day, and died Dec 30. The other was a 36-year-old from Menofia governorate who became ill Dec 26, was hospitalized Dec 29, and died 2 days later.The two women are listed as Egypt’s 42nd and 43rd avian flu case-patients, and their deaths are recorded as the country’s 17th and 18th fatalities from the disease.The WHO reported that investigators have found no epidemiologic link between the 36-year-old and another woman from Menofia governorate whose H5N1 illness was recently confirmed by the WHO. That 22-year-old woman was previously reported to be recovering in intensive care.Also, the WHO today confirmed the death of a 50-year-old Egyptian woman who was previously confirmed as the country’s 40th H5N1 case-patient on Dec 28. The woman, from Domiatt governorate, was hospitalized Dec 24 and died Dec 31. She is listed as Egypt’s 19th avian flu death.In its announcements about the women, the WHO said all three had contact with sick or dead poultry before they became ill.Elsewhere, a veterinary official in Vietnam told Tuoi Tre newspaper that the country’s most recent H5N1 patient, a 4-year-old boy from Son La province who died of the disease on Dec 16, may have contracted the virus from a wild bird, according to a Bloomberg News report today.That report says the official, Van Dang Ky, speaking at a national conference on bird flu control in Hanoi yesterday, noted that the boy’s family had brought home some wild birds from a hunting trip and also that samples from poultry in the area where the boy lived tested negative for the H5N1 virus.See also:Dec 27 CIDRAP News story “WHO confirms H5N1 case in Pakistan cluster”last_img read more

Luxurious tri-level home designed with library and master retreat

first_imgThree levels of luxury awaits a new owner at this monstrous four-bedroom property at Bunya.The 9 Birdson Place property was designed by owners Matthew Bailey-Lawrence, a civil engineer and construction manager, and Judy Bos an architect, who works as a project manager for Moreton Bay Regional Council.Standout features of the home include a library and a master retreat with a mirrored walk-in wardrobe. More from newsMould, age, not enough to stop 17 bidders fighting for this home6 hours agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor6 hours ago9 Birdsong Place, Bunya. 9 Birdsong Place, Bunya.Beautiful bushland surrounds the home, on a 4294sq m block, within the Windarra Estate.Selling agent Justin Comerford, from Ray White — Wilston said the property was built by Lindon Homes, a luxury house builder.last_img read more

Logitech G becomes official partner for Super League Gaming

first_imgThis includes Minecraft City Champs, League of Legends City Champs, and after school programs across the States. Super League Gaming is focused on the amateur and grassroots side of things.Ujesh Desai, Vice President and General Manager of Logitech Gaming commented: “At its core, gaming is all about play – whether you’re a top esports pro or a child discovering the joy of games for the first time.“We’ve been so impressed with Super League’s work to create respectful gaming environments. It’s vital to the industry, and we couldn’t be happier with this partnership.  We both have a common goal of supporting creativity and inclusion among gamers and esports pros, and we’re dedicated to turning the tide and removing toxicity from gaming.”Logitech G will be supporting City Champs tournament prizing, as well as collaborating with Super League on ‘social media initiatives’ and working with the company to develop original content that will be distributed through both Logitech G channels and SuperLeagueTV.Ann Hand, CEO, Super League Gaming noted: “Logitech G’s commitment to providing best-in-class PC and console gear aligns with Super League Gaming’s mission to deliver the preeminent competitive community experience for gamers.“Our organization embodies a diverse set of gaming talent where teamwork, friendship, and inclusivity are key tenets of our philosophy. With esport’s rapid growth, we’re confident this partnership will broaden our scope of talent and allow us to foster player diversity for the next generation of gaming professionals.”Esports Insider says: There has been a lot of noise from Super League Gaming recently with the company evidently aiming to have a big 2018. Partnering up with a company with the stature of Logitech G is a solid move, and makes sense for both parties. Logitech G has today announced that it has signed on as the official partner to Super League Gaming’s 2018 schedule. Ann Hand, SLGlast_img read more