AI Biomarker Demonstrates High Predictive Power for Lung Cancer Immunotherapy

first_img May 31, 2019 — Lunit announced an abstract presentation of its artificial intelligence (AI) precision medicine research portfolio at the American Society of Clinical Oncology (ASCO) Annual Meeting 2019, held May 31 – June 4 in Chicago. The accepted abstract highlights the feasibility of AI-based biomarkers in metastatic non-small cell lung cancer, based on the H&E analysis that predicts response to immune checkpoint inhibitors (ICI).The study evaluated the predictive value of AI versus PD-L1, the main biomarker for ICI, in terms of both its comparative predictive value as well as additive predictive value. According to the research, within PD-L1(+) patient group, the treatment response and progression-free survival (PFS) significantly differed depending on the AI score. The same results were obtained within the PD-L1(-) group.After reclassifying PD-L1(-) patient group based on the AI score, 52 percent of patients with high AI score had, in fact, shown response to ICI. These patients had three times longer PFS compared to the patients who had a low AI score. Similar outcomes were found among the PD-L1(+) patient group. Classified with AI profiling, 63 percent of low AI score patients were non-responsive to ICI. These patients had six times shorter PFS compared to high AI score patients.Additionally, in an AI analysis independent of PD-L1, the team was able to identify more patients that showed response to ICI. Among PD-L1(+) patient group, 49 percent of the patients were responsive to ICI, whereas 65 percent of patients within high AI score patient group showed response.Read the full ASCO abstract here.For more information: FacebookTwitterLinkedInPrint分享 Related Content News | Pediatric Imaging | August 14, 2019 Ultrasound Guidance Improves First-attempt Success in IV Access in Children August 14, 2019 – Children’s veins read more Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al. News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World’s Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive… read more News | Mammography | August 14, 2019 Imago Systems Announces Collaboration With Mayo Clinic for Breast Imaging Image visualization company Imago Systems announced it has signed a know-how license with Mayo Clinic. The multi-year… read more News | Colonoscopy Systems | August 06, 2019 Rise in Early Onset Colorectal Cancer Not Aligned With Screening Trends A new study finds that trends in colonoscopy rates did not fully align with the increase in colorectal cancer (CRC) in… read more News | Artificial Intelligence | August 08, 2019 Half of Hospital Decision Makers Plan to Invest in AI by 2021 August 8, 2019 — A recent study conducted by Olive AI explores how hospital leaders are responding to the imperative read more News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s… read more News | Artificial Intelligence | August 13, 2019 Artificial Intelligence Could Yield More Accurate Breast Cancer Diagnoses University of California Los Angeles (UCLA) researchers have developed an artificial intelligence (AI) system that… read more Image courtesy of Imago Systems News | Cardiovascular Ultrasound | August 07, 2019 Contrast Use in First Transthoracic Echocardiogram for Heart Failure Reduces Repeat Testing Heart failure is the fourth most common cause for all admission to U.S. hospitals, and it is the most common reason for… read more News | Artificial Intelligence | May 31, 2019 AI Biomarker Demonstrates High Predictive Power for Lung Cancer Immunotherapy Lunit presenting findings from study at ASCO 2019 News | CT Angiography (CTA) | August 06, 2019 Artificial Intelligence Improves Heart Attack Risk Assessment When used with a common heart scan, machine learning, a type of artificial intelligence (AI), does better than… read morelast_img read more

TypeScript 30 release candidate is here

first_imgAfter the announcement of Typescript 2.9 RC back in May, Microsoft’s TypeScript team came out with the release candidate of TypeScript 3.0 last week, unveiling features such as project references, extracting and spreading parameter lists with tuples, a new unknown type and API breaking changes among others. Let’s discuss the highlights of TypeScript 3.0 RC release. Project Reference functionality It allows TypeScript projects to depend on other TypeScript projects. Once these dependencies have been specified in the tsconfig.json file, you can easily split your code into smaller projects. It also provides TypeScript (and tools around it) a way to understand build ordering and output structure. Extracting and spreading parameter lists using tuples This functionality helps with reducing the overloading amount for functions of varied parameter lengths. Also, there is no need to write different overloads to support functions with different number of parameters. TypeScript 3.0 allows to better model scenarios like these by allowing rest parameters to be generic, and concluding those generics as tuple types. This, in turn, demands for richer tuple types to model scenarios such as optional parameters at the end of a parameter list, a final parameter which can be a rest parameter along with empty parameter lists. A new ‘unknown’ type Apart from these features, the new unknown type feature can accommodate APIs that uses variable of any value but requires type checking. Support for the JSX defaultProps There is also support for the JSX defaultProps used in React. These defaultProps allow the developers to define default values for props during creation of a component, such as a source for an Image component. TypeScript 3.0 RC also supports a new type alias called LibraryManagedAttributes in the JSX namespace. LibraryManagedAttributes is just a helper type that tells TypeScript what attributes a JSX tag accepts. Using this general type helps model React’s specific behavior for things such as defaultProps and propTypes. Apart from these features, there are API breaking changes API Breaking Changes The internal method LanguageService#getSourceFile is removed, after being deprecated for two years. The function TypeChecker#getSymbolDisplayBuilder and its associated interfaces are removed. The deprecated functions escapeIdentifier and unescapeIdentifier are removed. TypeScript 3.0 release is scheduled for sometime later this month. For more information on the latest TypeScript 3.0 RC release, check out the official Microsoft Blog. Read Next How to work with classes in Typescript How to install and configure TypeScriptlast_img read more

Cirq 040 released for writing quantum circuits

first_imgCirq is a Python library for writing quantum circuits and running them against quantum computers created by Google. Cirq 0.4.0 is now released and is available on GitHub. Changes in Cirq 0.4.0 themes The API is now more pythonic and more consistent with respect to breaking changes and refactoring. The simulation is faster. New functionality in Cirq 0.4.0 The following functions, parameters are added. cirq.Rx, cirq.Ry, and cirq.Rz cirq.XX, cirq.YY, cirq.ZZ, and cirq.MS related to the Mølmer–Sørensen gate cirq.Simulator cirq.SupportsApplyUnitary protocol is added to specify fast simulation methods cirq.Circuit.reachable_frontier_from and cirq.Circuit.findall_operations_between cirq.decompose sorted(qubits) and cirq.QubitOrder.DEFAULT.order_for(qubits) are now equivalent cirq.experiments.generate_supremacy_circuit_[…] dtype parameters are added to control the precision versus speed of simulations cirq.TrialResult helper methods (dirac_notation / bloch_vector / density_matrix) cirq.TOFFOLI and cirq.CCZ can be raised to powers Breaking changes in Cirq 0.4.0 Most of the gate classes have been standardized. They can now take an exponent argument and have a name which is of the form NamePowGate. For example, RotXGate is now XPowGate and it no longer takes rads, degs, or half_turns. The xmon gate set has now been merged into the common gate set. The capability marker classes have been replaced by magic method protocols. As an example, gates now just implement a _unitary_ method as opposed to inheriting from KnownMatrix. cirq.Extensions and cirq.PotentialImplementation are removed. Many decomposition classes and methods have been moved from* to cirq.*. Example: is now cirq.EjectPhasedPaulis. The classes and methods related to line placement are moved into Notable bug fixes A two-qubit gate decomposition will no longer produce a glut of single qubit gates. When multi-line entries are given, circuit diagrams stay aligned. They now include “same moment” indicators. The false-positives and false-negatives are fixed in cirq.testing.assert_circuits_with_terminal_measurements_are_equivalent. Many repr methods returning code are fixed that assumed from cirq import * instead of import cirq. Example code now runs in both Python 2 and Python 3 without the need for transpilation. Notable dev changes The test files now import cirq instead of just specific modules. There is better testing and packaging of scripts. The package versions for Python 2 and Python 3 are no longer different. cirq.value_equality decorator is added. New cirq.testing methods and classes are added. Additions to contrib cirq.contrib.acquaintance: New utilities for defining permutation gates cirq.contrib.paulistring: Utilities for optimizing non-Clifford operations which are separated by Clifford operations cirq.contrib.tpu: Utilities for converting circuits into an executable form to be used on cloud TPUs. This requires TensorFlow. Read next Google AdaNet, a TensorFlow-based AutoML framework Graph Nets – DeepMind’s library for graph networks in Tensorflow and Sonnet A new Model optimization Toolkit for TensorFlow can make models 3x fasterlast_img read more

Have your say at TICOs Open Forum Sessions

first_img<< Previous PostNext Post >> Friday, December 2, 2016 Tags: TICO Travelweek Group Posted bycenter_img TORONTO — Here’s your chance to have your voice heard! TICO will be holding Open Forum Sessions to gain insight from industry members about the Travel Industry Act, 2002 and Ontario Regulation 26/05.Led by the Ontario Government, the goal of the review is to increase regulatory efficiency, improve consumer protection, and reduce regulatory burdens on business.According to TICO, “these sessions are an opportunity for you to receive some valuable information as well as ask questions, provide feedback and network with your peers.”TICO will present information on the all-in-pricing requirement that comes into force on Jan. 1, 2017 and will review the consultation process. It will also present a number of priority issues and welcome feedback from attendees on areas such as registration, financial requirements, the Compensation Fund, e-Commerce and education standards.Sessions are free of charge and all Ontario travel agency owners and travel agents are welcome to attend.More news:  War of words between Transat, Group Mach ramps upLocates and dates are as follows:Jan. 10: Toronto/Mississauga, TICO Offices (2700 Matheson Blvd E, Suite 402, West Tower), 4:00-6:30 p.m.Jan. 11: Scarborough, Radisson Hotel Toronto East (55 Hallcrown Place), 4:00-6:30 p.m.Jan. 24: Toronto/Mississauga, TICO Offices (2700 Matheson Blvd E., Suite 402, West Tower), 2:00-4:30 p.m.Jan. 26: London, Delta London Armouries (325 Dundas St), 4:00-6:30 p.m.Feb. 8: Cambridge/Kitchener, Four Points by Sheraton (210 Preston Parkway), 4:00-6:30 pmSnacks and refreshments will be provided at each session. More sessions will be held around the province in early 2017 and will be announced shortly.Agents can confirm their attendance by emailing TICO at no later than Dec. 16. Space is limited.For more information, contact Susan Janko at (905) 624-6241 ext. 233 or email Share Have your say at TICO’s Open Forum Sessionslast_img read more

Can you guess which Canadian city made Frommers list of top vacation

first_img NEW YORK — If your clients are fresh out of ideas on where to travel to in 2017, Frommer’s – which will celebrate its 60th anniversary next year – has revealed its annual list of the best places to travel.A team of award-winning editors and writers around the world has compiled an honour roll list of top vacation places. Whether these destinations are enjoying a resurgence, honouring a milestone or anniversary, or simply because the moment is ripe for wider appreciation, they’re all primed and ready for travellers to visit in 2017.The 17 honourees are (in no particular order):•   Montréal, Quebec, for the confluence of celebrations surrounding its 375th birthday and the 150th anniversary of Canada•   Karasjok, Norway, the best place in the world for Northern Lights during a peak year for that phenomenon•   Bermuda, amidst a boom in development of its luxury tourism amenities and expecting the America’s Cup in May and June•   The Pantanal, South America’s massive and wondrous inland tropical wetlandsMore news:  Apply now for AQSC’s agent cruise rates•   The Mississippi River, long called “the Spine of America,” bursting with a fast-growing cruise industry•   Paris, France, because its tourism has dropped in the past year, but it remains as magical as ever•   Sulawesi, Indonesia, an under-appreciated island of tiny monkeys, vibrantly colored birds, and astonishing cultural rituals•   San Francisco and the Bay Area, which marks the 50th anniversary of the famous Summer of Love with a bounty of events•   Fátima, Portugal, commemorating the centenary of its miracle and vibrant with history, architecture and beaches•   Nashville, Tennessee, for its food, whip-smart population, music, and ideal location for viewing the August 21 solar eclipse•   The Panama Canal, newly expanded with a more-than-$5 billion set of locks•   Nan Madol, Micronesia, because its ancient black basalt temples and palaces are in danger of imminent destruction by natural forces•   Volcanoes National Park, Rwanda, the only region where you can see mountain gorillas in the wild, and where tourism is transforming lifeMore news:  Help Princess Cruises break the world record for largest vow renewal at sea•   Martin Luther’s Germany which will spend the year mounting concerts and events for the 500th anniversary of the reformer’s world-changing deed•   Katahdin Woods and Waters, Maine, 87,000 pristine acres of forests and streams just inscribed as a National Monument•   Haida Gwaii, British Columbia, a recent holiday spot for Prince William and Kate, for its unique wilderness and centuries old cultural links•   Doha, Qatar, which is challenging its flashier neighbors Dubai and Abu Dhabi with new attractions, flights, and hotelsThere is one bonus destination that Frommer’s felt compelled to include – Cuba. Frommer’s is not confident Cuba will remain an option for Americans. Donald J. Trump is threatening to restrict Americans’ right to travel there, hotel rates are ballooning, flights are being cut, and the death of Fidel Castro raises new uncertainties. For those reasons, Frommer’s inscribed it—with hope that travel remains open and growing—as its 18th top destination. Share Travelweek Group Monday, December 12, 2016 Tags: Frommers, Montrealcenter_img Can you guess which Canadian city made Frommer’s list of top vacation spots? Posted by << Previous PostNext Post >>last_img read more

You wont believe how long the worlds longest flight will be

first_imgYou won’t believe how long the world’s longest flight will be Share SINGAPORE – Is there a limit to how long you can tolerate being on a plane? At what point does that crying baby or your seatmate’s constant snoring break your resolve and cause you to tear out your hair?Singapore Airlines will soon find out once it launches the world’s longest nonstop commercial flight on Oct. 11. Travelling between Singapore’s Changi Airport and Newark Liberty Airport, the extra loooooong-haul flight will travel over 16,000 kilometres and last 18 hours and 45 minutes.We know what you’re thinking – that’s an unbearably long time to be watching movies starring The Rock. But Singapore Airlines is doing everything it can to make sure the flight is not only pleasant, but ultra comfortable.For one thing, it takes place on the new A350-900ULR (ultra-long-range) featuring a two-class layout (67 Business Class seats and 94 Premium Economy). That’s right – no uncomfortable Economy seats on this bad boy!More news:  Save the dates! Goway’s Africa Roadshow is backSecond, the plane is outfitted with several features to enhance comfort and reduce jetlag, namely higher ceilings, larger windows, an extra wide body and special lighting. Its carbon composite airframe also allows for improved air quality (yes, you actually breathe better onboard).And as long as it may be, the 18-hour flight is actually the quickest way to get one from city to the other. “The flights will offer our customers the fastest way to travel between the two cities – in great comfort, together with Singapore Airlines’ legendary service – and will help boost connectivity to and through the Singapore hub,” said Mr. Goh Choon Phong, Singapore Airlines’ CEO.The route will initially be served three times a week, departing Singapore on Monday, Thursday and Saturday. Daily operations will kick off Oct. 18 after an additional A350-900ULR aircraft enters service. Posted by Friday, June 1, 2018 center_img << Previous PostNext Post >> Travelweek Group Tags: Singapore Airlineslast_img read more

Groups can save 1500 per person with Avalon Waterways

first_img TORONTO — Avalon Waterways is giving travel agents a new way to close a group sale, by offering clients a savings of $1,500 per person on select river cruises.The cruise line has announced $1,500 off per person on a host of its Active Discovery Cruises for 2019. Bookings must be confirmed by Dec. 18, 2018.The offer applies to nearly 60 departures of the cruises along the Rhône, Rhine and Danube rivers.On an Active Discovery cruise, passengers have the choice each day of three types of free shore excursions: a Classic (usually a walking tour with local guide), a Discover (a taste of cultural immersion such as sampling cheese and beer at an ancient abbey), or an Active (such as a guided hike, jog or bike tour).Group rates and benefits apply to as few as eight clients travelling together. For more information go to Travelweek Group Groups can save $1,500 per person with Avalon Waterways Tags: Avalon Waterways Posted bycenter_img Share Tuesday, November 13, 2018 << Previous PostNext Post >>last_img read more

Boeing to pay US100 million to crash families communities

first_img Wednesday, July 3, 2019 CHICAGO — Boeing says it will pay US$100 million over several years to families and communities affected by two crashes of its 737 Max plane that killed 346 people.The company announced today that some of the money will go toward living expenses and to cover hardship suffered by the families of dead passengers.Boeing faces dozens of lawsuits over the accidents.Relatives of passengers on a Lion Air Max that crashed off the coast of Indonesia agreed to try to settle through mediation, but families of passengers killed in an Ethiopian Airlines crash are waiting until more is known about the accidents.Preliminary investigations point to the role played by new software that pushed the planes’ noses down. Boeing is updating the software. Max jets have been grounded worldwide since March. Share By: The Associated Press Boeing to pay US$100 million to crash families, communities Tags: boeing << Previous PostNext Post >>last_img read more

In Costa Rica cigar bars puff away – for now

first_imgFrom the print editionThe “Control of Tobacco and its Harmful Effects on Health Bill,” signed into law by President Laura Chinchilla, has been in effect since March with the blessing of the Constitutional Chamber of the Supreme Court (Sala IV), but in Escazú you can still get a smoke.It’s going to cost you, though: $2 for a one-day private membership at 9oN Escazú, an upscale new cigar and spirits bar on Avenida Escazú, southwest of San José. A month-long membership runs $25 and $250 lets you puff at will for a year.“This project started about a year ago in August,” said 9oN Escazú General Manager Michael Arnswald. “The smoking ban wasn’t really in our plans, but we were able to make adjustments.”Adjustments mean charging for memberships for entry into an exclusive, private smoking club with a selection of about 50 different cigars and a bar stocked with what Arnswald says is one of the best selections of single-malt scotch in Costa Rica.“We’re trying to bring our customers an elegant lounge feel, where they can have a drink and relax with a cigar,” Arnswald said.The anti-smoking law, which was upheld by the Sala IV against a March challenge to its constitutionality, prohibits smoking in places such as bars, restaurants, public buildings, casinos, bus stops and taxi stands. It also raised taxes on cigarettes by ₡20 ($0.04 cents) per cigarette and requires tobacco companies to print text and photo warnings about the dangers of smoking on at least 50 percent of cigarette boxes. Honduras, Guatemala and Panama have similar legislation, as do six South American countries (TT, March 23).Arnswald said that making 9oN Escazú a private club sidesteps legislation, and the club has taken other steps as well.“We have a high-powered air scrubbing system,” he said. “We don’t put any smoke out into the public sphere. Our smoke removal system is large enough for a 2,500 square-foot place, and here we have about 900 square feet.”Because the anti-smoking law prohibits smoking in any place where food is prepared, the club does not serve food.Additionally, the front of the club is clearly marked with warnings that minors and nonsmokers are prohibited from entering.Inside, the setting is geared to an upscale clientele. iPads with automated ordering systems are mounted on each table with full cigar and drink menus. Members can scroll through the club’s cigar selections and access descriptions and tasting notes, such as: “Black pepper and coffee bean flavors transition into rich leather and a sweet cappuccino finish.”The ambience is geared to attract not just foreign aficionados but the emerging Tico middle class with a taste for luxury products, said Arnswald. The market for cigars is developing in Costa Rica the way that wine markets grew here, Arnswald said.9oN Escazú isn’t the only business in town trying to cultivate a demand for fine cigars. La Casa del Habano opened its doors in the western San José neighborhood of Rohrmoser late last year.Luis Garcia, general manager at La Casa del Habano, said he feels confident shops like his and 9oN Escazú are in the right, but he admitted, things are a little uncertain at this point.“The problem,” he said, “is that all of this is very new. There are no regulations yet and there’s no application of the law yet, and so everyone is waiting to see what’s going to happen in the future.”One difference between the two businesses, Garcia said, is La Casa del Habano is set up more like a tobacco store while 9oN Escazú has the appearance of a bar. Garcia is the Costa Rica distributor for Habano cigars and counts 9oN Escazú as a customer. His store offers a credit program for regular customers who are allowed to enjoy cigars they’ve purchased in the store.“I don’t believe there’s any problem [with 9oN Escazú’s arrangement],” Garcia said. “No one’s freedom is being impinged upon and nobody feels uncomfortable there, because the whole world knows when they go into 9 North that it’s a place for smokers.”Health Vice Minister Sissy Castillo, however, said that according to the law, any workplace is a “prohibited site.”Article 4, Section B of the law defines a workplace as any “place that utilizes one or more workers or volunteers.” Article 5, Section B declares any workplace “as defined by Article 4 of this law” to be “spaces 100 percent free from the exposure to tobacco smoke.”“The problem isn’t so much for the smokers that are going to go in there,” Castillo said. “A place, even though it is a private site, becomes a workplace for the employees who are going to be there attending the clients at the bar. … From this perspective, they would be falling under non-compliance with the law.”Castillo said the reglamentos, or rules that guide the law’s application, are still being worked out at the Health Ministry, and she expects the norms to go to a public hearing next week.She doesn’t mince words about the intended effects of the law.“We are convinced that this is going to benefit the health of nonsmokers as much as smokers,” Castillo said. “The idea is to discourage the consumption of tobacco.”In the meantime, 9oN Escazú’s Arnswald said the bar is operating at about 50 to 60 percent capacity on a nightly basis, with 50/50 mix of Ticos and foreigners showing up for a puff and a tipple. He hopes to drive that up to 100 percent soon and to keep “educating customers on the nuances of smoking and how to enjoy a good cigar.”n Facebook Comments No related posts.last_img read more

Costa Rica cops seize 900 kilos of cocaine at Pacific port

first_imgCosta Rican anti-drug police on Sunday seized 901 kilograms of cocaine and arrested nine members of a drug trafficking crew, among them four Colombians, two Nicaraguans, a Panamanian and two Costa Ricans.Public Security Minister Mario Zamora announced the bust following a three-day police operation in Quepos, on the central Pacific coast 170 kilometers west of the capital.Zamora said the drugs likely came from Colombia and were discovered in a luxury residence 1 km from the center of the port town, hidden underneath mattresses.Officials say drug traffickers used the house as a storage point for shipments north to the United States – the world’s biggest illicit drug consumer nation – via Mexico.Police also confiscated four vehicles and three firearms during the operation.Costa Rica has seized some 5.3 tons of cocaine already this year, officials said. Facebook Comments No related posts.last_img read more